We have flown into Tampa twice, once with American and once with Southwest. Both times because the price was fantastic versus Orlando. Since we rent a vehicle with unlimited miles, the savings from flying into Tampa is worth it. The trip is about an hour and 10-15 minutes depending on traffic. The plus side to all this is once you leave the airport it is all freeway. When you consider that an average trip from Orlando International is about 20-25 minutes assuming traffic is good, then the extra 40-45 minutes is not that bad. We are going again in March and I have already been searching Tampa and Orlando prices. Considering where I live, metro Houston, the drive is about the same as going from one end of the city limits to the other.