It changes hour to hour.
A day or two ago 75 was closed for awhile up around Ocala.
Yesterday the turnpike was closed near 192 for a few hours.
Earlier today there was a collision on the Turnpike that shut all southbound lanes for over an hour near exit 272.
The best advice I have is to have a good map with you in case you need to detour, don't let your gas tank get below 1/4 in case you get stuck in traffic, and hope for the best.
Anne