Yes, Belle. Just head straight along Sand Lake Rd to I4 and head west to Exit 26A and follow the signs to the park of your choice! Couldn't be simpler (unless you want Animal Kingdom, in which case you want Exit 26D!)
Thanks for the thread Belle5. I got the Wyndham Orlando on Priceline, and will be staying offsite for the first time. I too was wondering about the commute.