That's our usual route when driving (we are in Trenton and cross the border near Syracuse).
We stayed at the Best Western in Columbia, just off the interstate and very near Ft. Jackson. Sorry I can't give you more precise location on it right now. We picked it from CAA and it was a decent place with restaurants close by. If memory serves, it was on the far side of town. Nice thing about the location was that leaving in the morning, rush hour wasn't a problem. Not too far from the turn off to the I26.
About 30-40 minutes further down the road is Orangeburg on I 26. We stayed at the Fairfield Inn (on points) and thought it was really good. Nice breakfast in the morning. Again, close to restaurants.