My doctor told me that it is better if you wait a full hour, that 30 minutes is the minimum. I was having so many issues that I took her advice and started waiting the full hour. It really isn't that difficult to do for me. I get up take the pill, get ready for work, etc. By the time I get to the office it has been an hour. I then make my coffee (decaf, so no need to have it first thing) and a bowl of oatmeal.