Just flew out of Worcester for April vacation....really a nice experience. Not to mention...$63 to park the car for 10 days!!
So...it will take you an hour to drive from Sanford to WDW. DME, from gate to resort, is about 70 mins, but could be about 90 mins. I've had a time of 50 mins and a time of 85 mins.....with lots closer to the 65-70 min mark.
A car service will run you about $200, r/t...maybe a bit less depending on who you use. We are using a car service in Oct for two couples. Since we are spending only $159 pp, r/t, for airfare, that $200 isn't bad at all.
If you are planning on renting a car, I found it to be easy to do.
Budget/
Avis were right in front of the terminal/parking lot. Very easy. I believe Hertz and
Alamo/National were there as well, but didn't pay too much attention.
Long story short...
Sanford to resort (gate to resort actually)....about 90 mins.
DME to resort.....70-90 mins.