I live about 40 miles from San Antonio, so I actually never stayed in the city. Most name brand hotels should be fine. If you'll have transportation, I may suggest staying somewhere near the convention center. San Antonio is a great convention town, and most visitor services are nearby, and the convention center hotels will be on or near the beautiful River Walk and the RiverCenter shopping mall. At the shopping mall you can catch river taxis and tourist tour boats to see the city from the river. Be aware, though, that San Antono hotels do have a reputaion for being on the expensive side. If you want a very historic hotel, the Menger is one of the oldest hotels (Teddy Roosevelt and the Rough Riders stayed there), it is very near the river walk, next door to the Alamo (remember that?) and within easy walking distance of most tourist attractions downtown, including Ripley's, a wax museum, the IMAX theater, the Institute of Texas Cultures, the Alamo Dome, and the Tower of the Americas. You would need a car to get to Sea World and Fiesta Texas. San Antonio is considered a pretty tourist friendly city.