Your question has been the subject of past discussions. Most people do the I-75 route via Atlanta, using the I-285 bypass of Atlanta if rush hour is involved and always using the I-475 bypass at Macon. However, there are a core of people who prefer I-65 through Alabama to Montomery and then US 231 from Montgomery to Cottondale, FL and I-10.
I've done both. US231 goes through small towns with lower speed limits and traffic lights (and southern cops). The bypass around Dothan is also one traffic light after another. So I prefer the Georgia routing. If you want some variety then do one route on the way down and the other on the way back home.
BobK/Orlando