Ruthie, when we went in June we had a 6x6 book. We kept the pages in the book and pulled them out for each signing. It kept them safer that way! We have a couple of pages we accidentally left on the clipboard and they got wet.
If you go to dinner and have several characters who are going to sign, then I'd pull all those out and put them on a clipboard, but then put them back into your book as soon as you can.
I'm still debating whether I'm going that route again, or spiral binding my pages for this trip. I figure if I cut the page a bit longer on the binding side, I can cut it off once I get home and then slide it into my book. Does that makes sense?