Okay been lurking for a bit.... we are in Kalamazoo Michigan and everyone thinks I'm nuts but it looks like it's quite a bit cheaper to drive to Orlando even though we have 4 kids (10,7,2,&4) and we're not gonna be able to go for a year or more but just going to hang out subscribe, read posts and learn for you all.... I'm not nuts to do it right? It seems to be much more economical even though not as convenient, but it's an experience also, right?!
Up in Grand Rapids here. We've been doing it every other year since 2008. First trip was three kids, second was four, and in 2012 we had five. The last two we had nursing children younger than 1 year with us (10, 8, 6, 3, 9 months).
Drove straight through both ways and passed through K'Zoo on our way. US 131, I-94, I-69, I-65, I-24, I-75, Florida Turnpike. It's the most efficient way from our area. Fewest tolls, fewest miles, best speed limits, etc. And if you get a flat tire on the way, Hoss' Tire just south of Ft. Wayne is open until 6:00 pm (life saver!). Mr. Hoss will greet you at the door and work you right in ahead of the locals so you can be on your way.
I've mapped out I-75 all the way and cutting across Ohio to I-77 as alternatives. 77 is a lot farther, but a prettier drive (we took it to Hilton Head, SC one year). Also a lot more tolls. 75 is such a main north south road with all the Eastern Michigan traffic I prefer to avoid.
If you're not night drivers, you still want to try to time your departure to avoid Indianapolis, Nashville, Chattanooga, and Atlanta rush hours. Tennessee is a beautiful stretch of road heading into Chattanooga. A lot of our marathoners will leave in the afternoon with the intent of going all night. That way, the kids are excited early, fall asleep during the long stretch, and we are nearly to Florida before they wake up so they're excited again!
US-31 is supposed to be updated to freeway grade all the way through to Indianapolis in a couple years. I'm looking forward to that as it will take a good 40 miles off our trip.
Depending on what you're driving, if you can get a hold of a cargo topper before you go, with four (five for us) kids in a car, it's a life saver! Seven people in a mini-van just wouldn't work otherwise with all the luggage and strollers. Had to bring two last time. Hope to be down to just a single stroller for out next trip.
If you plan on getting a room on the way down, you'll need to plan early travelling with six. Not many places can handle your family comfortably. Try to decide where you'll be stopping, then make a reservation early to make sure you have space. We aren't like smaller families that can pull into the first place we see and expect them to have room (without having to get two rooms or pack the three older kids in one bed).