We drive to Florida at least 4 times a year - (2012 we did 5 drives to Disney) from the Chicago burbs. We have tried several ways - our GPS keeps wanting us to take I65. Before we had the GPS, we usually drove I57 to I24. We tried the GPS routing of I65 and weren't happy. Supposedly according the GPS it should be about 20 -30 minutes faster - however in reality it took the same amount of time. We have tried the I65 route 3 times and had the same result so we now stick to our I57 route. I know that I65 has a higher speed limit than IL, but IN has 2 speed limits - one for trucks and one for cars where IL has raised the speed limit for trucks to the same as cars. So when trucks pass each other, they are going the same as you and you don't get sandwiched between trucks as you do in IN. When we took I65, getting caught between trucks ate up a lot of time. Also, there seems to be a lot less truck traffic on I57 than I65.