No, DME is only for transportation to and from Disney-operated resorts on the Disney property. Also when you stay at a Disney hotel DME gives you pickup information based on your outgoing flight time; you don't call them to specify what you want. If they are staying close to the airport I would guess that hotel would probably have their own airport shuttle of some kind. Otherwise they will have to arrange for a taxi or some other transportation. Mears (which does operate DME for Disney by the way) is an example of a service where you can arrange a pickup. UPDATE: After reading subsequent replies I realized I didn't understand the question. I thought it was if DME would pick you up at a non-Disney hotel. Now I get it that the question is about taking DME to the airport from a Disney resort but not on the flight day.