Last time I went, I had one blister, but it was because I had a cut on my foot, and used a band-aid. The band-aid slipped, and alas, blisters. Anyway, here was my regimen:
Target gad Dr. Scholl's liquid powder on clearance for $2/bottle. I bought almost a whole case, cause I have bad feet problems. I put lots of that on every morning. I would dump a LOT of powder into my shoes, as well as my socks, and I had no problems.
According to the Unofficial Guide to Walt Disney World by Bob Sehlinger (an AMAZING resource if you don't have one):
Sergeant Blisterblaster's Guide to Happy Feet at Walt Disney World
1. On Your Feet! Get up, Easy-Boy rider: when you go to Walt Disney World, you'll have to walk a lot farther than to the refrigerator. You can log 5-12 miles a day no problem at the Disney parks, so now's the time to get them dogs in shape. Start with some short walks around the neighborhood and increase your distance gradually until you can do six miles on weekends without CPR.
2. A-TEN-SHUN! During your pre-Disney training program, pay attention when those puppies growl. They will give you a lot of information about your feet and the appropriateness and fit of your shoes. Listen up! No walking in flip-flops, loafers, or sandals. Wear well-constructed, broken-in running or hiking shoes. If you feel a "hot spot", that means a blister is developing. The most common sites for blisters are the heels, the toes, and the balls of your feet. If you note a tendency to develop a hot spot in the same place every time you walk, cover it prophylactically with Moleskin (available in drugstores without a prescription) before you set out. No, Sofa Bunny, I did not tell you to wear condoms on your feet!
Prophylactically means to anticipate the problem and treat it in advance. One more thing: keep your toenails cut short, and straight across.
3. Sock It Up, Trainee! Good socks are as important as good shoes. When you walk, your feet sweat like a mule in a peat bog, and moisture increases friction. To minimize friction, wear two pairs of socks. The pair next to your feet should ideally be polypropylene thin socks or sock liners. The outer sock can be either a natural fiber like cotton or wool, or a synthetic fiber. To further combat moisture, dust your dogs with some antifungal talcum powder.
4. Who Do You Think You Are, John Wayne? Don't be a hero. The time to take care of a foot problem is the minute you notice it. Carrt a small foot emergency kit for your platoon. The kit should contain gauze, Betadyne antibiotic ointment, moleskin or spenco second skin*, scissors**, a sewing needle or some such to drain blisters, as well as matches to sterilize the needle***. An extra pair of socks and some talc is optional.
5. Bite the Bullet! If you develop a hot spot, cover it ASAP with moleskin or spenco second skin. Cut the covering large enough to cover the skin surrounding the hot spot. If you develop a blister, air out and dry your foot. Next, drain the fluid, but do NOT remove the top skin. Clean the area with your Betadyne, place a dauze square over the blister, and cover the whole shooting match with moleskin. If you do not have moleskin or spenco second skin, do not try to cover the hot spot or blister with band-aids. Band-aids slip and wad-up.
6. Take Care of Your Platoon. If you have a couple of young green troops in your outfit, they might not sound off when a hot spot comes on. Stop several times a day and check their feet. If you forgot your emergency foot kit and a problem arises, don't be reluctant to call the Disney medics. They have all the stuff you need to keep your command in action.
*spenco second skin is AWESOME! I prefer it to the moleskin!!!!!!
** with all of the security, precut some moleskin at the hotel, or at home if you can't bring scissors with you.
*** you can also sterilize with purell
I used these steps, and except for my stupidity with band-aid, remained blister free!!! I don't mean to contradict anything anyone said either. Just passing along what was in the book!