QEW
Peace Bridge (Fort Erie)
190
I90
I79
US Route 19 (absolutely obey all posted speed limits on Route 19!)
I77
I26
I95
I4
WDW
The above route is quickest and most scenic. As for best...well that is subjective. From the north end of Route 19 to Wythville, VA you are in the heart of the mountains. Very beautiful. You will also go through two large mountain tunnels around Bluefields, VA. If driving at night through the mountains be very aware of animals at the side of the road. Keep your eyes open! Also, early morning in the mountains can mean plenty of fog until it burns off. Fog isn't usually so bad in the summer months though. Took my wife this route 2 summers ago. She'd only driven I75. She loved this route because it was scenic and cut about 3 hours off the drive. There aren't as many hotel/gas/food exits on this route but that should only be of concern in the winter. If you are travelling on the weekends I would suggest calling ahead for hotels. Many hotels through the mountainous areas can book up on weekends especially if a college football mini-camp has opened in the area. Learned this the hardway! Have a great trip!